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Iron(II)‐Catalyzed Aerobic Biomimetic Oxidation of N‐Heterocycles
Author(s) -
Manna Srimanta,
Kong WeiJun,
Bäckvall JanE.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102483
Subject(s) - dehydrogenation , catalysis , substrate (aquarium) , chemistry , hydroquinone , electron transfer , cobalt , environmentally friendly , combinatorial chemistry , organic chemistry , ecology , oceanography , biology , geology
Abstract Herein, an iron(II)‐catalyzed biomimetic oxidation of N‐heterocycles under aerobic conditions is described. The dehydrogenation process, involving several electron‐transfer steps, is inspired by oxidations occurring in the respiratory chain. An environmentally friendly and inexpensive iron catalyst together with a hydroquinone/cobalt Schiff base hybrid catalyst as electron‐transfer mediator were used for the substrate‐selective dehydrogenation reaction of various N‐heterocycles. The method shows a broad substrate scope and delivers important heterocycles in good‐to‐excellent yields.