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Frontispiece: The Xanthate Route to Indolines, Indoles, and their Aza Congeners
Author(s) -
Zard Samir Z.
Publication year - 2020
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202085661
Subject(s) - xanthate , indole test , chemistry , pyrrole , radical , aryl radical , aryl , ring (chemistry) , indoline , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , alkyl
Convergent routes to a variety of indolines, indoles, oxindoles, and their aza analogues involving radical additions of xanthates are described while discussing three different approaches. The first is the least general and relies on the generation of aryl or heteroaryl radicals starting from diazonium salts. The second involves radical addition to N ‐allylanilines followed by ring‐closure onto the aromatic core. The last approach hinges on the direct modification of indoles by radical addition to the pyrrole subunit of the indole nucleus. For more information, see the Review by S. Zard et al. on page 12689 ff.