Enantioselective Alkynylation of Isatins: A Combination of Metal Catalysis and Organocatalysis | Zendy

Jiang Dan | Zendy; Tang Pei | Zendy; Tan Qiuyuan | Zendy; Yang Zhao | Zendy; He Ling | Zendy; Zhang Min | Zendy

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Enantioselective Alkynylation of Isatins: A Combination of Metal Catalysis and Organocatalysis

Author(s) -

Jiang Dan,

Tang Pei,

Tan Qiuyuan,

Yang Zhao,

He Ling,

Zhang Min

Publication year - 2020

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202003118

Subject(s) - stereocenter , bifunctional , enantioselective synthesis , organocatalysis , alkynylation , catalysis , chemistry , combinatorial chemistry , organic chemistry

An efficient and catalytic asymmetric alkynylation of isatins has been developed using a bifunctional amidophosphine‐urea/AgBF 4 complex as the catalyst. By a combination of metal catalysis and organocatalysis, excellent enantioselectivities (up to 99 % ee ) and good yields are achieved. A wide range of both terminal alkynes and isatins are tolerated by this new catalyst system, providing access to structurally diverse propargylic alcohols with tetrasubstituted stereogenic centers in high efficiency.

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