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1D Self‐Assembly and Ice Recrystallization Inhibition Activity of Antifreeze Glycopeptide‐Functionalized Perylene Bisimides
Author(s) -
Adam Madeleine K.,
JarrettWilkins Charles,
Beards Michael,
Staykov Emiliyan,
MacFarlane Liam R.,
Bell Toby D. M.,
Matthews Jacqueline M.,
Manners Ian,
Faul Charl F. J.,
Moens Pierre D. J.,
Ben Robert N.,
Wilkinson Brendan L.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201800857
Subject(s) - recrystallization (geology) , antifreeze , antifreeze protein , supramolecular chemistry , cryoprotectant , perylene , chemistry , self assembly , materials science , nanotechnology , biophysics , crystallography , biochemistry , biology , microbiology and biotechnology , molecule , organic chemistry , crystal structure , cryopreservation , embryo , paleontology
Abstract Antifreeze glycoproteins (AFGPs) are polymeric natural products that have drawn considerable interest in diverse research fields owing to their potent ice recrystallization inhibition (IRI) activity. Self‐assembled materials have emerged as a promising class of biomimetic ice growth inhibitor, yet the development of AFGP‐based supramolecular materials that emulate the aggregative behavior of AFGPs have not yet been reported. This work reports the first example of the 1D self‐assembly and IRI activity of AFGP‐functionalized perylene bisimides (AFGP‐PBIs). Glycopeptide‐functionalized PBIs underwent 1D self‐assembly in water and showed modest IRI activity, which could be tuned through substitution of the PBI core. This work presents essential proof‐of‐principle for the development of novel IRIs as potential supramolecular cryoprotectants and glycoprotein mimics.