Premium
Back Cover: Alternative Mechanistic Strategy for Enzyme Catalysis in a Ni‐Dependent Lactate Racemase (LarA): Intermediate Destabilization by the Cofactor (Chem. Eur. J. 15/2017)
Author(s) -
Zhang Xiaoyong,
Chung Lung W.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605864
Subject(s) - cofactor , racemization , chemistry , catalysis , enzyme , stereochemistry , biochemistry
The unique role of a new (SCS)Ni cofactor in lactate racemase (LarA) is examined in this computational study. The Ni‐dependent cofactor could increase dehydrogenation barriers and particularly destabilize the NADH‐like pyruvate intermediates, due to the lower electrophilicity of the cofactor and the ring strain in the intermediates. This intermediate destabilization by a cofactor in LarA, which can promote racemization, is uncommon in enzymatic catalysis. More information can be found in the Full Paper by L. W. Chung, et al. on page 3623 ff.