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Palladium‐Catalyzed Asymmetric Arylation of Trifluoromethylated/Perfluoroalkylated 2‐Quinazolinones with High Enantioselectivity
Author(s) -
Zhou Bo,
Jiang Chunhui,
Gandi Vasudeva Rao,
Lu Yixin,
Hayashi Tamio
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201603105
Subject(s) - quinazolinone , palladium , chemistry , cationic polymerization , catalysis , ligand (biochemistry) , fluorine , combinatorial chemistry , organic chemistry , medicinal chemistry , receptor , biochemistry
Abstract Asymmetric arylation of 4‐fluoroalkyl‐2‐quinazolinone derivatives with arylboronic acids proceeded smoothly in the presence of a cationic palladium catalyst (1 mol %) coordinated with a chiral phosphinooxazoline (phox) ligand to create the corresponding fluorine‐containing arylated dihydroquinazolinones in high yields and with greater than 99 % ee .