Dynamic Combinatorial Enrichment of Polyconformational  D ‐/ L ‐Peptide Dimers | Zendy

Jadhav  Kirtikumar B. | Zendy; Lichtenecker  Roman J. | Zendy; Bullach Anke | Zendy; Mandal Bhubaneswar | Zendy; Arndt HansDieter | Zendy

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Dynamic Combinatorial Enrichment of Polyconformational D ‐/ L ‐Peptide Dimers

Author(s) -

Jadhav Kirtikumar B.,

Lichtenecker Roman J.,

Bullach Anke,

Mandal Bhubaneswar,

Arndt HansDieter

Publication year - 2015

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201405413

Subject(s) - antiparallel (mathematics) , dimer , peptide , chemistry , stereochemistry , biochemistry , physics , organic chemistry , quantum mechanics , magnetic field

D ‐/ L ‐Peptides such as gramicidin A (gA) adopt unique dimeric β ‐ helical structures of different topologies. To overcome their conformational promiscuity and enrich individual components, a dynamic combinatorial approach assisted by thiol tags was developed. This method led to identification of the preferential formation of antiparallel dimers under a broad range of conditions, which was independent of peptide side‐chain polarity. Exclusive formation of an antiparallel cyclic dimer was achieved in the presence of cesium ions.

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