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Cover Picture: Antithyroid Drugs and their Analogues Protect Against Peroxynitrite‐Mediated Protein Tyrosine Nitration—A Mechanistic Study (Chem. Eur. J. 4/2010)
Author(s) -
Bhabak Krishna P.,
Mugesh Govindasamy
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201090007
Subject(s) - peroxynitrite , nitration , chemistry , oxidative stress , tyrosine , antioxidant , thiourea , pharmacology , thyroid , biochemistry , medicine , organic chemistry , superoxide , enzyme
Commonly used thiourea‐based antithyroid drugs and their selenium analogues exhibit remarkable peroxynitrite‐scavenging activities and protect against peroxynitrite‐mediated protein tyrosine nitrations. This study suggests that the antioxidant activity of these compounds may protect the thyroid gland from oxidative and nitrosative stress during hyperthyroidism. For more details see the Full Paper by K. P. Bhabak and G. Mugesh on page 1175 ff.
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