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Unifying Metal and Brønsted Acid Catalysis—Concepts, Mechanisms, and Classifications
Author(s) -
Rueping Magnus,
Koenigs Rene M.,
Atodiresei Iuliana
Publication year - 2010
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201001140
Subject(s) - enantioselective synthesis , the renaissance , organocatalysis , catalysis , brønsted–lowry acid–base theory , chemistry , combinatorial chemistry , organic synthesis , field (mathematics) , metal , nanotechnology , biochemical engineering , organic chemistry , materials science , mathematics , engineering , art , pure mathematics , art history
Abstract Asymmetric catalysis is a key feature of modern synthetic organic chemistry. Traditionally, different combinations of ligands and metals are used to perform highly enantioselective reactions. Since the renaissance of organocatalysis in the early 2000s, tremendous improvement in the field of metal‐free catalysis has been achieved. Recently, the combination of transition metals and organocatalysts has allowed the development of new protocols enabling transformations that could not previously be realized. This article aims to present the latest contributions in the field of combined chiral Brønsted acid and metal catalyzed reactions, highlighting the advantages of these catalytic systems as well as describing the uncertainties regarding the molecular structure of the catalytically active species and the reaction mechanisms.