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Synthetic Fragments of Antigenic Lipophosphoglycans from Leishmania major and Leishmania mexicana and Their Use for Characterisation of the Leishmania Elongating α‐ D ‐Mannopyranosylphosphate Transferase
Author(s) -
Higson Adrian P.,
Ross Andrew J.,
Tsvetkov Yury E.,
Routier Françoise H.,
Sizova Olga V.,
Ferguson Michael A. J.,
Nikolaev Andrei V.
Publication year - 2005
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.200400563
Subject(s) - leishmania , leishmania mexicana , phosphodiester bond , transferase , chemistry , biochemistry , leishmania major , biology , enzyme , microbiology and biotechnology , parasite hosting , rna , world wide web , computer science , gene
Abstract The phosphorylated branched heptasaccharides 7 and 8 , the octasaccharide 9 and the phosphorylated trisaccharides 5 and 6 , which are fragments of the phosphoglycan portion of the surface lipophosphoglycans from Leishmania mexicana ( 5 ) or L. major ( 6 – 9 ), were synthesised by using the glycosyl hydrogenphosphonate method for the preparation of phosphodiester bridges. The compounds were tested as acceptor substrates/putative inhibitors for the Leishmania elongating α‐ D ‐mannosylphosphate transferase.