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Inside Cover: Aliphatic Halogenase Enables Late‐Stage C−H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity (ChemBioChem 6/2016)
Author(s) -
Zhu Qin,
Hillwig Matthew L.,
Doi Yohei,
Liu Xinyu
Publication year - 2016
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201600114
Subject(s) - surface modification , chemistry , antibacterial activity , bromine , cover (algebra) , staphylococcus aureus , combinatorial chemistry , halogenation , stereochemistry , bacteria , organic chemistry , biology , mechanical engineering , genetics , engineering
The inside cover picture shows that a newly discovered stand‐alone non‐heme iron halogenase WelO5 from cyanobacterium Hapalosiphon welwitschii (background image) can selectively modify antibiotic molecule 12‐ epi ‐fischerindole U (left) by late‐stage oxidative functionalization of an aliphatic C−H group with bromine to give 13 R ‐bromo‐12‐ epi ‐fischerindole U (right) with enhanced antibacterial activity against human pathogen Staphylococcus aureus (bottom). More information can be found in the communication by X. Liu et al. on page 466 in Issue 6, 2016 (DOI: 10.1002/cbic.201500674).