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A “Diels‐Alderase” at Last
Author(s) -
Townsend Craig A.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100431
Subject(s) - cycloaddition , chemistry , biocatalysis , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , reaction mechanism
Diels this Alder your thinking? Electrocyclization reactions are exceedingly rare in metabolic pathways. Why is this so? Recently a [4+2] cycloaddition catalyzed by a monofunctional “Diels–Alderase” has been characterized. How does a 500‐fold rate enhancement shown by this enzyme stack up?
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