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Identification of the First Bacterial Monoterpene Cyclase, a 1,8‐Cineole Synthase, that Catalyzes the Direct Conversion of Geranyl Diphosphate
Author(s) -
Nakano Chiaki,
Kim HyoKyoung,
Ohnishi Yasuo
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100330
Subject(s) - monoterpene , streptomyces clavuligerus , sesquiterpene , cyclase , chemistry , stereochemistry , terpenoid , biochemistry , enzyme , antibiotics , amoxicillin , clavulanic acid
Cycling gear: A sesquiterpene cyclase (SC) homologue, CnsA, from Streptomyces clavuligerus has been identified as a monoterpene cyclase that catalyzes the conversion of GPP into 1,8‐cineole (see scheme). This suggests that bacterial SC homologues could include monoterpene cyclases, similar to plant SC homologues.