Premium
Transformation with Tryptophan Halogenase Genes Leads to the Production of New Chlorinated Alkaloid Metabolites by a Medicinal Plant
Author(s) -
van Pée KarlHeinz
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100016
Subject(s) - catharanthus roseus , tryptophan , indole alkaloid , indole test , alkaloid , biosynthesis , transformation (genetics) , enzyme , gene , monoterpene , biochemistry , biology , chemistry , stereochemistry , botany , amino acid
Catharanthus roseus produces chlorinated monoterpene indole alkaloids after the introduction of bacterial tryptophan halogenase genes into this medicinal plant. In the case of chlorination in the 5‐position, the substrate specificity of an enzyme further downstream in the pathway also had to be changed. The background image is taken from Wikimedia Commons.