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Two New Alkaloids from Brachystemma calycinum and Their Inhibitory Effects on Lymphocyte Proliferation
Author(s) -
Lu Qing,
Zhang Li,
He GuoRong,
Liang HengXing,
Du GuanHua,
Cheng YongXian
Publication year - 2007
Publication title -
chemistry and biodiversity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.427
H-Index - 70
eISSN - 1612-1880
pISSN - 1612-1872
DOI - 10.1002/cbdv.200790244
Subject(s) - chemistry , moiety , stereochemistry , inhibitory postsynaptic potential , lymphocyte , immunology , biology , neuroscience
Two new alkaloids, brachystemidines F ( 1 ) and G ( 2 ), were isolated from the roots of Brachystemma calycinum. Their structures were established on the basis of detailed spectroscopic analyses, including extensive NMR and HR‐MS techniques. Compound 2 , which exhibits an unusual N ‐hydroxydiazenyl (HONN) moiety, is a potent immunosuppressive agent, as demonstrated by inhibition of mouse T‐ and B‐lymphocyte proliferation, with IC 50 values of 6.33 and 5.60 μg/ml, resp.
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