Open AccessCollateral state and the effect of endovascular reperfusion therapy on clinical outcome in ischemic stroke patients
Author(s) -
Gerber Johannes C.,
Petrova Marketa,
Krukowski Pawel,
Kuhn Matthias,
Abramyuk Andrij,
Bodechtel Ulf,
Dzialowski Imanuel,
Engellandt Kay,
Kitzler Hagen,
Pallesen LarsPeder,
Schneider Hauke,
Kummer Ruediger,
Puetz Volker,
Linn Jennifer
Publication year - 2016
Publication title -
brain and behavior
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.915
H-Index - 41
ISSN - 2162-3279
DOI - 10.1002/brb3.513
Subject(s) - medicine , angiography , modified rankin scale , collateral circulation , stroke (engine) , radiology , cardiology , occlusion , ischemic stroke , ischemia , mechanical engineering , engineering
Abstract Purpose Clinically successful endovascular therapy ( EVT ) in ischemic stroke requires reliable noninvasive pretherapeutic selection criteria. We investigated the association of imaging parameters including CT angiographic collaterals and degree of reperfusion with clinical outcome after EVT . Methods In our database, we identified 93 patients with large vessel occlusion in the anterior circulation treated with EVT . Besides clinical data, we assessed the baseline Alberta Stroke Program Early CT score ( ASPECTS ) on noncontrast CT ( NCCT ) and CT angiography ( CTA ) source images, collaterals ( CT ‐ CS ) and clot burden score ( CBS ) on CTA and the degree of reperfusion after EVT on angiography. Three readers, blinded to clinical information, evaluated the images in consensus. Data‐driven multivariable ordinal regression analysis identified predictors of good outcome after 90 days as measured with the modified Rankin Scale. Results Successful angiographic reperfusion ( OR 26.50; 95%‐ CI 9.33–83.61) and good collaterals ( OR 9.69; 95%‐ CI 2.28–59.27) were independent predictors of favorable outcome along with female sex ( OR 0.35; 95%‐ CI 0.14–0.85), younger age ( OR 0.88; 95%‐ CI 0.83–0.92) and higher NCCT ASPECTS ( OR 2.54; 95%‐ CI 1.01–6.63). Outcome was best in patients with good collaterals and successful reperfusion, but there was no statistical interaction between collaterals and reperfusion. Conclusions CTA ‐collateral status was the strongest pretherapeutic predictor of favorable outcome in ischemic stroke patients treated with EVT . CTA ‐collaterals are thus well suited for patient selection in EVT . However, the independent effect of reperfusion on outcome tended to be stronger than that of CTA ‐collaterals.