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Characterization of the isomeric dialkylbarbituric acids formed by the reaction of barbiturates with diazoalkanes
Author(s) -
Harvey D. J.,
Nowlin J.,
Hickert P.,
Butler C.,
Gansow O.,
Horning M. G.
Publication year - 1974
Publication title -
biomedical mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0306-042X
DOI - 10.1002/bms.1200010509
Subject(s) - diazomethane , chemistry , proton magnetic resonance , mass spectrometry , organic chemistry , medicinal chemistry , chromatography , physics , nuclear magnetic resonance
Abstract The reaction of barbituric acids with diazoalkanes (diazomethane and diazoethane) gives the N , N ′‐dialkylbarbituric acids as the major products. Gas chromatograms of the reaction products show up to four additional peaks. These have been shown by mass and proton magnetic resonance spectrometry to be produced by the two isomeric N , O ‐dialkylbarbituric acids (1,4‐ and 1,2‐dialkylbarbituric acids) and the two O , O ′‐dialkyl isomers.