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N ‐Acyl amino acids and their impact on biological processes
Author(s) -
Hanuš Lumír,
Shohami Esther,
Bab Itai,
Mechoulam Raphael
Publication year - 2014
Publication title -
biofactors
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.204
H-Index - 94
eISSN - 1872-8081
pISSN - 0951-6433
DOI - 10.1002/biof.1166
Subject(s) - serine , glycine , neuroprotection , amino acid , chemistry , pharmacology , biochemistry , biology , enzyme
Abstract Over the last two decades a large number of N ‐long‐chain acyl amino acids have been identified in the mammalian body. The pharmacological activities of only a few of them have been investigated and some have been found to be of considerable interest. Thus arachidonoyl serine is vasodilatory and neuroprotective, arachidonoyl glycine is antinociceptive, and oleoyl serine rescues bone loss. However, the pathophysiological/biochemical roles of these amides are mostly unknown. © 2014 BioFactors, 40(4):381–388, 2014