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Revisiting β‐Catenin Signaling in T‐Cell Development and T‐Cell Acute Lymphoblastic Leukemia
Author(s) -
Bigas Anna,
Guillén Yolanda,
Schoch Leonie,
Arambilet David
Publication year - 2020
Publication title -
bioessays
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 184
eISSN - 1521-1878
pISSN - 0265-9247
DOI - 10.1002/bies.201900099
Subject(s) - axin2 , wnt signaling pathway , leukemia , stem cell , biology , cancer research , catenin , lymphoblastic leukemia , function (biology) , gene , immunology , genetics
Abstract β‐Catenin/ CTNNB1 is critical for leukemia initiation or the stem cell capacity of several hematological malignancies. This review focuses on a general evaluation of β‐catenin function in normal T‐cell development and T‐cell acute lymphoblastic leukemia (T‐ALL). The integration of the existing literature offers a state‐of‐the‐art dissection of the complexity of β‐catenin function in leukemia initiation and maintenance in both Notch‐dependent and independent contexts. In addition, β‐catenin mutations are screened for in T‐ALL primary samples, and it is found that they are rare and with little clinical relevance. Transcriptional analysis of Wnt family members ( Ctnnb1 , Axin2 , Tcf7 , and Lef1 ) and Myc in different publicly available T‐ALL cohorts indicates that the expression of these genes may correlate with T‐ALL subtypes and/or therapy outcomes.