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Desymmetrization of Achiral Heterobicyclic Alkenes through Catalytic Asymmetric Hydrophosphination
Author(s) -
Sadeer Abdul,
Ong Yew Jin,
Kojima Tadayuki,
Foo Ce Qing,
Li Yongxin,
Pullarkat Sumod A.,
Leung PakHing
Publication year - 2018
Publication title -
chemistry – an asian journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.18
H-Index - 106
eISSN - 1861-471X
pISSN - 1861-4728
DOI - 10.1002/asia.201801061
Subject(s) - desymmetrization , catalysis , chemistry , asymmetric carbon , organic chemistry , enantioselective synthesis , optically active
Abstract Asymmetric addition of diarylphosphines to oxa‐ and azabicyclic alkenes proceeded in the presence of a chiral phosphapalladacycle catalyst and a mild acid at room temperature to give exclusively the enantioenriched addition products in excellent yields and good selectivities. Three new chiral carbon centers were generated stereoselectively by the catalytic hydrophosphination reaction.