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Synthesis, Antioxidant, and Cytotoxic Activities of N ‐ A zole Substituted Thiomorpholine Derivatives
Author(s) -
Reddy Putta Ramachandra,
Reddy Guda Mallikarjuna,
Padmaja Adivireddy,
Padmavathi Venkatapuram,
Kondaiah Paturu,
Krishrra Siva
Publication year - 2014
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201300299
Subject(s) - hela , chemistry , antioxidant , cytotoxic t cell , ascorbic acid , substituent , stereochemistry , organic chemistry , in vitro , biochemistry , food science
A new class of N ‐azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC 50 values of 10.1 and 30.0 µM, respectively.