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Novel Benzimidazo[2,1‐ c ][1,4]thiazinone Derivatives with Potent Activity Against HSV‐1
Author(s) -
Galal Shadia A.,
Naem Shweekar I. El,
Nezhawy Ahmed O.H. El,
Ali Mohamed. A.,
Diwani Hoda I. El
Publication year - 2011
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.201000252
Subject(s) - potency , chemistry , benzimidazole , herpes simplex virus , thiazine , stereochemistry , biological activity , chemical synthesis , carboxylic acid , virus , pharmacology , biochemistry , in vitro , medicinal chemistry , organic chemistry , virology , biology
Abstract The synthesis of new 2‐carboxymethylsulfanylmethyl‐1 H ‐benzimidazole and 1,3‐dihydro‐4 H ‐benzo[4′,5′]imidazo[2,1‐ c ][1,4]thiazine‐4‐one‐8‐carboxylic acid derivatives was investigated. The antiviral activity of compounds 1–14 was tested against the herpes simplex virus 1. Compounds 5 and 14 showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50 µg, respectively. Compounds 5 and 14 showed higher potency than Acyclovir at doses of 20 µg and 50 µg.