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Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation
Author(s) -
Nosrati Hamed,
Salehiabar Marziyeh,
Attari Elahe,
Davaran Soodabeh,
Danafar Hossein,
Manjili Hamidreza Kheiri
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4069
Subject(s) - chemistry , biocompatibility , differential scanning calorimetry , thermogravimetric analysis , iron oxide nanoparticles , nanoparticle , fourier transform infrared spectroscopy , nuclear chemistry , magnetic nanoparticles , chemical engineering , iron oxide , nanotechnology , organic chemistry , materials science , physics , engineering , thermodynamics
We report the synthesis of iron oxide magnetic nanoparticles (IONPs) coated with various natural amino acids (AAs) using a one‐pot reaction in an aqueous medium. Several AAs, which contained hydrophilic and hydrophobic groups, were selected to study their effects on size, morphology and toxicity of IONPs. Functionalized IONPs were characterized using X‐ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and scanning and transmission electron microscopies. Furthermore, vibrating sample magnetometry analysis shows these nanoparticles have excellent magnetic properties. Cellular toxicity of IONPs was also investigated on HFF2 cell lines. The AA‐coated IONPs are non‐toxic and biocompatible. Natural AA‐coated IONPs show a potential for their development in in vitro and in vivo biomedical fields due to their non‐toxicity, good ζ ‐potential and related small size and narrow size distribution.