Biological activity  of selected boronic acids and their derivatives | Zendy

AdamczykWoźniak Agnieszka | Zendy; KomarovskaPorokhnyavets Olena | Zendy; Misterkiewicz Bogusław | Zendy; Novikov Volodymyr P. | Zendy; Sporzyński Andrzej | Zendy

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Biological activity of selected boronic acids and their derivatives

Author(s) -

AdamczykWoźniak Agnieszka,

KomarovskaPorokhnyavets Olena,

Misterkiewicz Bogusław,

Novikov Volodymyr P.,

Sporzyński Andrzej

Publication year - 2012

Publication title -

applied organometallic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.53

H-Index - 71

eISSN - 1099-0739

pISSN - 0268-2605

DOI - 10.1002/aoc.2880

Subject(s) - chemistry , aspergillus niger , biological activity , antimicrobial , antibacterial activity , antifungal , escherichia coli , phenylboronic acid , staphylococcus aureus , biochemistry , bacteria , microbiology and biotechnology , organic chemistry , in vitro , biology , gene , genetics , catalysis

A series of substituted phenylboronic acids and benzoxaboroles were evaluated for their antimicrobial activity . Antibacterial and antifungal action activity of several compounds was tested against Escherichia coli 67, Staphylococcus aureus 209‐p, Mycobacterium luteum VCM B‐868, Aspergillus niger VCM F‐1119 and Candida tenuis VCM Y‐70. Substituted phenylboronic acids have low biological activity against all the investigated species. Benzoxaboroles reveal higher biological activity in comparison with the corresponding acids. The highest activity was observed for small benzoxaborole molecules, and the unsubstituted benzoxaborole has only slightly lower biological activity as compared with the 5‐fluoro‐substituted one (AN2690). The compound possessing two oxaborole fragments has very high biological activity towards Mycobacterium luteum and both investigated fungi. Copyright © 2012 John Wiley & Sons, Ltd.

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