Premium
Synthesis, characterization and in vitro cytotoxic effects of new organotin(IV)‐2‐maleimidopropanoates
Author(s) -
Khan M. I.,
Baloch Musa Kaleem,
Ashfaq Muhammad
Publication year - 2006
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.1083
Subject(s) - chemistry , carboxylate , octahedron , stereochemistry , solid state , ligand (biochemistry) , in vitro , mössbauer spectroscopy , crystallography , crystal structure , biochemistry , receptor
Abstract Synthesis, spectral properties and in vitro cytotoxic behaviour of five new diorganotin(IV) complexes having general composition R′ 2 SnR 2 [R′ = 2‐maleimidopropanoic acid and R = Me( 1 ), Et( 2 ), n ‐Bu( 3 ), Ph( 4 ), Bz( 5 )] have been investigated. Various spectroscopic methods like solid‐state FT IR, 119m Sn Mössbauer and solution‐state multinuclear NMR ( 1 H, 13 C and 119 Sn) have been employed for structural elucidation. In the solid state, [R 2 Sn(IV)] 2+ moieties interacted with carboxylate group of the ligand in octahedral arrangement, while in the solution state 1–3 showed hyper‐coordination and 4 and 5 were tetrahedral. All these results were consistent with elemental analysis and MS data. These complexes were also screened for in vitro anti‐tumour, anti‐leishmanial and anti‐fungal activities, and structure–activity relationship have been proposed. Copyright © 2006 John Wiley & Sons, Ltd.