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Pseudouridimycin: The First Nucleoside Analogue That Selectively Inhibits Bacterial RNA Polymerase
Author(s) -
Chellat Mathieu F.,
Riedl Rainer
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201708133
Subject(s) - nucleoside , polymerase , rna polymerase , antibiotics , nucleoside analogue , chemistry , rna , biology , microbiology and biotechnology , biochemistry , enzyme , gene
Seek, and ye shall find : After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screening. The broad‐spectrum nucleoside‐analogue inhibitor pseudouridimycin is selective for bacterial RNA polymerase and elicits very low resistance rates.