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Nickel‐Catalyzed Enantioselective Conjunctive Cross‐Coupling of 9‐BBN Borates
Author(s) -
Chierchia Matteo,
Law Chunyin,
Morken James P.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706719
Subject(s) - enantioselective synthesis , electrophile , chemistry , nickel , catalysis , stereospecificity , aryl , ligand (biochemistry) , diamine , boron , combinatorial chemistry , organic chemistry , biochemistry , alkyl , receptor
Abstract Catalytic enantioselective conjunctive cross‐coupling between 9‐BBN borate complexes and aryl electrophiles can be accomplished with Ni salts in the presence of a chiral diamine ligand. The reactions furnish chiral 9‐BBN derivatives in an enantioselective fashion and these are converted to chiral alcohols and amines, or engaged in other stereospecific C−C bond forming reactions.