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Remote C−H Functionalization by a Palladium‐Catalyzed Transannular Approach
Author(s) -
De Sarkar Suman
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201604404
Subject(s) - surface modification , palladium , alicyclic compound , catalysis , chemistry , combinatorial chemistry , molecule , organic chemistry
Now within reach : In the remote C−H arylation of alicyclic amines the key step is the transannular coordination of the palladium catalyst (see picture, DG=directing group). This strategy is convenient for the late‐stage functionalization of complex bioactive molecules in order to probe structure–activity relationships.