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Back Cover: One‐Pot N2C/C2C/N2N Ligation To Trap Weak Protein–Protein Interactions (Angew. Chem. Int. Ed. 28/2016)
Author(s) -
Zhao Lei,
Ehrt Christiane,
Koch Oliver,
Wu YaoWen
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201603828
Subject(s) - ligation , int , c terminus , chemistry , cover (algebra) , biophysics , biochemistry , stereochemistry , microbiology and biotechnology , biology , computer science , amino acid , engineering , mechanical engineering , operating system
Weak protein‐‐protein interactions (PPIs) are readily trapped by one‐pot chemical protein ligations. In their Communication on page 8129 ff., Y.‐W. Wu and co‐workers describe a facile method for trapping weak PPIs in an unbiased manner using proximity‐induced ligations. To expand the chemical ligation spectrum, novel C‐terminus to C‐terminus (C2C) and N‐terminus to N‐terminus (N2N) ligation strategies (head‐to‐head and tail‐to‐tail in the fish model in the picture) were developed.