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Total Synthesis of Nosiheptide
Author(s) -
Wojtas K. Philip,
Riedrich Matthias,
Lu JinYong,
Winter Philipp,
Winkler Thomas,
Walter Sophia,
Arndt HansDieter
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201603140
Subject(s) - total synthesis , natural product , stereochemistry , core (optical fiber) , antibiotics , chemistry , combinatorial chemistry , computer science , biochemistry , telecommunications
Total synthesis of the bismacrocyclic thiopeptide antibiotic nosiheptide was achieved through the assembly of a fully functionalized linear precursor followed by consecutive macrocyclizations. Key features are a critical macrothiolactonization and a mild deprotection strategy for the 3‐hydroxypyridine core. The natural product was identical to isolated authentic material in terms of spectral data and antibiotic activity.
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