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Catalytic Enantioselective Reaction of α‐Aminoacetonitriles Using Chiral Bis(imidazoline) Palladium Catalysts
Author(s) -
Kondo Masaru,
Nishi Tomoki,
Hatanaka Tsubasa,
Funahashi Yasuhiro,
Nakamura Shuichi
Publication year - 2015
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201503098
Subject(s) - enantioselective synthesis , catalysis , imidazoline receptor , chemistry , palladium , reaction conditions , organic chemistry , combinatorial chemistry , medicine
Abstract The catalytic enantioselective reaction of diphenylmethylidene‐protected α‐aminoacetonitriles with imines has been developed. Good yields and diastereo‐ and enantioselectivities were observed for the reaction of various imines using chiral bis(imidazoline)/Pd catalysts. The reaction of α‐aminonitriles with di‐ tert ‐butyl azodicarboxylate afforded chiral α,α‐diaminonitriles in high yields with high enantioselectivities.