Ruthenium(II)/N‐Heterocyclic Carbene Catalyzed [3+2] Carbocyclization with Aromatic NH Ketimines and Internal Alkynes | Zendy

Zhang Jing | Zendy; Ugrinov Angel | Zendy; Zhao Pinjing | Zendy

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Ruthenium(II)/N‐Heterocyclic Carbene Catalyzed [3+2] Carbocyclization with Aromatic NH Ketimines and Internal Alkynes

Author(s) -

Zhang Jing,

Ugrinov Angel,

Zhao Pinjing

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201209031

Subject(s) - imine , ruthenium , intramolecular force , alkyne , carbene , chemistry , catalysis , medicinal chemistry , polymer chemistry , combinatorial chemistry , photochemistry , stereochemistry , organic chemistry

Convenient and highly efficient : Indenamines were synthesized using the title reaction, which occurs at ambient temperature, in the absence of oxidants or other metal salts, and in nonpolar solvents. A proposed mechanism involves imine‐directed activation of an aromatic CH bond, alkyne insertion, and carbocyclization by intramolecular imine insertion into Ru–alkenyl linkages.

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