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Catalytic Diastereoselective Petasis Reactions
Author(s) -
Muncipinto Giovanni,
Moquist Philip N.,
Schreiber Stuart L.,
Schaus Scott E.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201103271
Subject(s) - catalysis , chemistry , exploit , combinatorial chemistry , scheme (mathematics) , reaction conditions , organic chemistry , computer science , mathematics , computer security , mathematical analysis
Multicomponent Petasis reactions : The first diastereoselective Petasis reaction catalyzed by chiral biphenols that enables the synthesis of syn and anti β‐amino alcohols in pure form has been developed. The reaction exploits a multicomponent approach that involves boronates, α‐hydroxy aldehydes, and amines (see scheme).
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