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Controlled Delivery Using Oligonucleotide‐Capped Mesoporous Silica Nanoparticles
Author(s) -
Climent Estela,
MartínezMáñez Ramón,
Sancenón Félix,
Marcos María D.,
Soto Juan,
Maquieira Angel,
Amorós Pedro
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201001847
Subject(s) - oligonucleotide , mesoporous silica , nanoparticle , mesoporous material , nanotechnology , computer science , chemistry , materials science , dna , organic chemistry , biochemistry , catalysis
Caps off! A single‐stranded oligonucleotide capped the pores on the surface of a silica mesoporous support, which contained an entrapped guest. In the presence of a complementary strand, the “molecular lock” on the delivery vehicle was opened and the entrapped guests were selectively released.