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Synthesis and Conformational Study of Water‐Soluble, Rigid, Rodlike Oligopiperidines
Author(s) -
Semetey Vincent,
Moustakas Demetri,
Whitesides George M.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200502991
Subject(s) - piperidine , solid state , phase (matter) , chemistry , solid phase synthesis , polymer chemistry , state (computer science) , polymer science , crystallography , stereochemistry , chemical engineering , combinatorial chemistry , materials science , organic chemistry , computer science , engineering , algorithm , biochemistry , peptide
An oligomeric backbone of piperidine rings can be synthesized by solution or solid‐phase synthesis. These oligomers adopt well‐defined, rodlike structures with all the piperidine residues in chair conformations (see picture) both in solution (D 2 O, CD 3 OD) and the solid state.