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Aptamer‐Directed Self‐Assembly of Protein Arrays on a DNA Nanostructure
Author(s) -
Liu Yan,
Lin Chenxiang,
Li Hanying,
Yan Hao
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200501089
Subject(s) - aptamer , nanostructure , dna origami , dna , nanotechnology , dna nanotechnology , crossover , self assembly , thrombin , nanoscopic scale , chemistry , biophysics , materials science , biology , computer science , biochemistry , microbiology and biotechnology , platelet , artificial intelligence , immunology
Lined up nicely : The self‐assembly of proteins on rationally designed nanostructures into periodic linear arrays has been demonstrated. Triple‐crossover DNA tiles 1 containing an aptamer sequence (AS) to which thrombin specifically binds can form linear arrays 2 . These direct the ultimate positioning of thrombin proteins (green spheres) in 3. This system should facilitate the construction of other such programmable nanoscale protein arrays.