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High‐Affinity Multivalent DNA Binding by Using Low‐Molecular‐Weight Dendrons
Author(s) -
Kostiainen Mauri A.,
Hardy John G.,
Smith David K.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200500066
Subject(s) - chemistry , dendrimer , spermine , dna , molecular binding , combinatorial chemistry , biophysics , molecule , biochemistry , organic chemistry , biology , enzyme
Nine spermines are better than one : Compound G2 exhibits high‐affinity, salt‐independent DNA binding as a consequence of the spermine array on its surface. Comparison with smaller dendrons and model compounds indicates a clear multivalency effect on binding.