Elucidation of the Mechanism of the 1,6‐Cuprate Addition to Acceptor‐Substituted Enynes through  13 C Kinetic Isotope Effects: Experimental and Theoretical Studies | Zendy

Mori Seiji | Zendy; Uerdingen Marc | Zendy; Krause Norbert | Zendy; Morokuma Keiji | Zendy

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Elucidation of the Mechanism of the 1,6‐Cuprate Addition to Acceptor‐Substituted Enynes through 13 C Kinetic Isotope Effects: Experimental and Theoretical Studies

Author(s) -

Mori Seiji,

Uerdingen Marc,

Krause Norbert,

Morokuma Keiji

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200462976

Subject(s) - kinetic isotope effect , cuprate , chemistry , kinetic energy , acceptor , mechanism (biology) , substrate (aquarium) , isotope , alkyl , computational chemistry , photochemistry , materials science , organic chemistry , deuterium , physics , doping , nuclear physics , optoelectronics , quantum mechanics , condensed matter physics , oceanography , geology

A combination of experimental and theoretical studies of 13 C kinetic isotope effects have led to a comprehensive mechanistic picture of the 1,6‐cuprate addition to acceptor‐substituted enynes. In the rate‐determining step, the new bond is formed from the triple bond of the substrate to the incoming alkyl group (see scheme).

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