Highly Reactive, General, and Long‐Lived Catalysts for Coupling Heteroaryl and Aryl Chlorides with Primary Nitrogen Nucleophiles | Zendy

Shen Qilong | Zendy; Shekhar Shashank | Zendy; Stambuli James P. | Zendy; Hartwig John F. | Zendy

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Highly Reactive, General, and Long‐Lived Catalysts for Coupling Heteroaryl and Aryl Chlorides with Primary Nitrogen Nucleophiles

Author(s) -

Shen Qilong,

Shekhar Shashank,

Stambuli James P.,

Hartwig John F.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200462629

Subject(s) - denticity , nucleophile , catalysis , aryl , yield (engineering) , palladium , ligand (biochemistry) , chemistry , decomposition , primary (astronomy) , nitrogen , combinatorial chemistry , coupling (piping) , medicinal chemistry , reactive intermediate , organic chemistry , materials science , physics , crystal structure , astronomy , metallurgy , alkyl , biochemistry , receptor

Resisting pathways for decomposition followed by palladium complexes of monodentate ligands is one characteristic of the highly reactive but long‐lived catalyst generated from the Josiphos ligand L and palladium. It catalyzes under mild conditions the coupling of primary amines with chloropyridines and chloroarenes in high yield with low catalyst loadings (see scheme).

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