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Powerful Chiral Phase‐Transfer Catalysts for the Asymmetric Synthesis of α‐Alkyl‐ and α,α‐Dialkyl‐α‐amino Acids
Author(s) -
Kitamura Masanori,
Shirakawa Seiji,
Maruoka Keiji
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200462257
Subject(s) - enantioselective synthesis , catalysis , alkylation , alkyl , glycine , chemistry , alanine , amino acid , phase (matter) , organic chemistry , combinatorial chemistry , biochemistry
The catalytic performance of the chiral phase‐transfer catalyst 1 (0.1–0.01 mol %) in the asymmetric alkylation of protected glycine and alanine derivatives exceeds that of existing catalysts. The reaction is used in the enantioselective synthesis of structurally diverse natural and non‐natural α‐alkyl and α,α‐dialkyl‐α‐amino acids.