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Iron‐Catalyzed Cross‐Coupling Reactions: Efficient Synthesis of 2,3‐Allenol Derivatives
Author(s) -
Fürstner Alois,
Méndez María
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200352441
Subject(s) - propargyl , catalysis , chirality (physics) , combinatorial chemistry , chemistry , coupling reaction , organic chemistry , physics , quantum mechanics , chiral symmetry breaking , nambu–jona lasinio model , quark
Reliable chirality transfer is one of the major advantages of a novel synthesis of 2,3‐allenols from propargyl epoxides (see scheme) catalyzed by inexpensive and environmentally benign iron salts. The reactions proceed very rapidly in excellent yields and with moderate to good diastereoselectivity in favor of the syn ‐configured product.