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IPy 2 BF 4 ‐Promoted Intramolecular Addition of Masked and Unmasked Anilines to Alkynes: Direct Assembly of 3‐Iodoindole Cores
Author(s) -
Barluenga José,
Trincado Mónica,
Rubio Eduardo,
González José M.
Publication year - 2003
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200351303
Subject(s) - intramolecular force , indole test , chemistry , metal , combinatorial chemistry , nitrogen , aniline , medicinal chemistry , organic chemistry
All at once! Indoles can be assembled and iodinated in a one‐pot process (see scheme) from anilines and their derivatives. This metal‐free addition of nitrogen compounds to alkynes is a clean reaction that is promoted by iodonium cations. Such a process provides a general pathway towards utilization of the biologically relevant indole core.