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Propargylation of Carbonyl Compounds by Umpolung of Propargylpalladium Complexes with Diethylzinc
Author(s) -
Tamaru Yoshinao,
Goto Sachio,
Tanaka Akihiro,
Shimizu Masamichi,
Kimura Masanari
Publication year - 1996
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199608781
Subject(s) - umpolung , diethylzinc , nucleophile , alcohol , chemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis , enantioselective synthesis
The first nucleophilic additions of propargylpalladium complexes have been achieved with the reactions (a), R 1 = H, Me, Ph, R 2 = H, Me, Ph, SiMe 3 . In these reactions in addition to the homopropargyl alcohol 1 , the allenyl alcohol 2 was only formed for R 1 = H, R 2 = Me, Ph and the ethylallene 3 for R 1 = Ph, R 2 = H.
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