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Catalytic Enantioselective Protonation of Enolates
Author(s) -
Fehr Charles,
Galindo José
Publication year - 1994
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.199418881
Subject(s) - protonation , enantioselective synthesis , catalysis , stereoselectivity , proton , chemistry , organic chemistry , stereochemistry , medicinal chemistry , physics , nuclear physics , ion
“A textbook example for stereoselective synthesis” —that is how one of the referees described the title reaction. With only 0.2 equivalents of a chiral proton donor, prochiral enolates such as 1 are protonated to give 2 .
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