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Asymmetric Synthesis of 2‐Alkylcyclohexanones on Solid Phases
Author(s) -
Worster Paul M.,
McArthur Colin R.,
Leznoff Clifford C.
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197902211
Subject(s) - yield (engineering) , reagent , sequence (biology) , chemistry , combinatorial chemistry , enantiomeric excess , enantioselective synthesis , stereochemistry , materials science , organic chemistry , catalysis , metallurgy , biochemistry
Asymmetric syntheses on a kind of “Synthetic enzyme” appear highly promising, as shown by the reaction sequence illustrated below: (S) ‐2‐methyl‐and (S) ‐2‐propycyclohexanone have each been obtained in 80% chemical yield and 95 and 60% optical yield, respectively. The chiral reagent (1) can be re‐used.