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Remote meta ‐CH Olefination of Phenylacetic Acids Directed by a Versatile U‐Shaped Template
Author(s) -
Deng Youqian,
Yu JinQuan
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201409860
Subject(s) - phenylacetic acid , nitrile , combinatorial chemistry , chemistry , glycine , ring (chemistry) , ligand (biochemistry) , stereochemistry , organic chemistry , amino acid , biochemistry , receptor
meta‐CH olefination of phenylacetic acid derivatives has been achieved using a commercially available nitrile‐containing template. The identification of N‐formyl‐protected glycine as the ligand (Formyl‐Gly‐OH) was crucial for the development of this reaction. Versatility of the template approach in accommodating macrocyclopalladation processes with different ring sizes is demonstrated.
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