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Association between bleomycin hydrolase and Alzheimer's disease in caucasians
Author(s) -
Farrer Lindsay A.,
Abraham Carmela R.,
Haines Jonathan L.,
Rogaeva Ekaterina A.,
Song Youqiang,
McGraw Walker T.,
Brindle Nicholas,
Premkumar Smita,
Scott William K.,
Yamaoka Larry H.,
Saunders Ann M.,
Roses Allen D.,
Auerbach Sanford A.,
Sorbi Sandro,
Duara Ranjan,
PericakVance Margaret A.,
St GeorgeHyslop Peter H.
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410440515
Subject(s) - association (psychology) , alzheimer's disease , bleomycin , disease , medicine , degenerative disease , oncology , psychology , chemotherapy , psychotherapist
Abstract A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with nondemented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.