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Basal forebrain neurons in the dementia of Parkinson disease
Author(s) -
Whitehouse Peter J.,
Hedreen John C.,
White Charles L.,
Price Donald L.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130304
Subject(s) - nucleus basalis , basal forebrain , dementia , neurochemical , neuroscience , cholinergic neuron , parkinson's disease , disease , cholinergic , degenerative disease , alzheimer's disease , medicine , psychology , pathology , central nervous system disease
Abstract Demented patients with Parkinson disease share certain neuropathological and neurochemical features with patients suffering from Alzheimer disease. Recently, loss of cholinergic neurons in the basal forebrain, particularly the nucleus basalis of Meynert, has been implicated in the pathophysiology of Alzheimer disease. The present investigation of 12 patients with Parkinson disease demonstrates that the demented patients with this disease also show a selective loss of cells in the nucleus basalis of Meynert, thus providing an important link between the dementias of Alzheimer disease and Parkinson disease.