Premium
Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis
Author(s) -
van Es Michael A.,
Schelhaas Helenius J.,
van Vught Paul W. J.,
Ticozzi Nicola,
Andersen Peter M.,
Groen Ewout J. N.,
Schulte Claudia,
Blauw Hylke M.,
Koppers Max,
Diekstra Frank P.,
Fumoto Katsumi,
LeClerc Ashley Lyn,
Keagle Pamela,
Bloem Bastiaan R.,
Scheffer Hans,
van Nuenen Bart F. L.,
van Blitterswijk Marka,
van Rheenen Wouter,
Wills AnneMarie,
Lowe Patrick P.,
Hu Guofu,
Yu Wenhao,
Kishikawa Hiroko,
Wu David,
Folkerth Rebecca D.,
Mariani Claudio,
Goldwurm Stefano,
Pezzoli Gianni,
Van Damme Philip,
Lemmens Robin,
Dahlberg Caroline,
Birve Anna,
FernándezSantiago Rubén,
Waibel Stefan,
Klein Christine,
Weber Markus,
van der Kooi Anneke J.,
de Visser Marianne,
Verbaan Dagmar,
van Hilten Jacobus J.,
Heutink Peter,
Hennekam Eric A. M.,
Cuppen Edwin,
Berg Daniela,
Brown Robert H.,
Silani Vincenzo,
Gasser Thomas,
Ludolph Albert C.,
Robberecht Wim,
Ophoff Roel A.,
Veldink Jan H.,
Pasterkamp R. Jeroen,
de Bakker Paul I. W.,
Landers John E.,
van de Warrenburg Bart P.,
van den Berg Leonard H.
Publication year - 2011
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.22611
Subject(s) - amyotrophic lateral sclerosis , angiogenin , odds ratio , medicine , concomitant , parkinson's disease , disease , oncology , angiogenesis
Abstract Objective: Several studies have suggested an increased frequency of variants in the gene encoding angiogenin ( ANG ) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, a few ALS patients carrying ANG variants also showed signs of Parkinson disease (PD). Furthermore, relatives of ALS patients have an increased risk to develop PD, and the prevalence of concomitant motor neuron disease in PD is higher than expected based on chance occurrence. We therefore investigated whether ANG variants could predispose to both ALS and PD. Methods: We reviewed all previous studies on ANG in ALS and performed sequence experiments on additional samples, which allowed us to analyze data from 6,471 ALS patients and 7,668 controls from 15 centers (13 from Europe and 2 from the USA). We sequenced DNA samples from 3,146 PD patients from 6 centers (5 from Europe and 1 from the USA). Statistical analysis was performed using the variable threshold test, and the Mantel‐Haenszel procedure was used to estimate odds ratios. Results: Analysis of sequence data from 17,258 individuals demonstrated a significantly higher frequency of ANG variants in both ALS and PD patients compared to control subjects ( p = 9.3 × 10 −6 for ALS and p = 4.3 × 10 −5 for PD). The odds ratio for any ANG variant in patients versus controls was 9.2 for ALS and 6.7 for PD. Interpretation: The data from this multicenter study demonstrate that there is a strong association between PD, ALS, and ANG variants. ANG is a genetic link between ALS and PD. ANN NEUROL 2011;70:964–973