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Loss of interhemispheric inhibition on the ipsilateral primary sensorimotor cortex in patients with brachial plexus injury: fMRI study
Author(s) -
Hsieh JenChuen,
Cheng Henrich,
Hsieh HsiuMin,
Liao KwongKum,
Wu YuTe,
Yeh TzuChen,
Ho LowTone
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.10149
Subject(s) - brachial plexus , sensorimotor cortex , functional magnetic resonance imaging , brachial plexus injury , medicine , magnetic resonance imaging , neuroscience , cortex (anatomy) , reduction (mathematics) , psychology , anesthesia , radiology , geometry , mathematics
Abstract This functional magnetic resonance imaging study verified an antagonistic pattern in which a concomitant deactivation of ipsilateral primary sensorimotor (SM1) was coupled to the contralateral SM1 activation in healthy controls during unimanual hand grasping. Of note, dramatic reduction of ipsilateral SM1 deactivation (loss of antagonistic pattern) was observed during movement of intact hands by patients with unilateral brachial plexus injury. We propose that the disappearance of the antagonistic pattern of SM1 activities in the patients with brachial plexus injury reflects a reduction of interhemispheric inhibition, which may mirror an adaptive mechanism to functional status.